1. Traditional Chinese Medicine for Breast Cancer: A Review - PMC
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A total of 18% of global breast cancer (BC) deaths are attributed to BC in China, making it one of the five most common cancers there. There has been a steady rise in BC morbidity and mortality in women in the last few years and it is now a leading ...
2. Zhu Xiaofeng | Experimental Research
Zhu Xiaofeng is the deputy director of the Experimental Research Department and a professor in the State Key Laboratory of Oncology in South China.
sun yat-sen university cancer center,Sun Yat-sen University Cancer Center,SYSUCC
3. Combination therapy with micellarized cyclopamine and temozolomide ...
Jun 27, 2017 · Glioblastoma multiforme (GBM) is the most common and deadly brain cancer, characterized by its aggressive proliferation to adjacent tissue and ...
// Yu-Jie Liu 1 , Ying-Cong Ma 1 , Wen-Jie Zhang 1 , Zhen-Zhen Yang 1 , De-Sheng Liang 1 , Zhi-Fu Wu 2 and Xian-Rong Qi 1 1 Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China 2 School of Materials Science and Engineering, Baise University, Guangxi Baise, 533000, PR China Correspondence to: Xian-Rong Qi, email: qixr@bjmu.edu.cn Keywords: cyclopamine, temozolomide, hedgehog pathway, synergistic effect, glioma Received: January 28, 2017 Accepted: April 03, 2017 Published: April 18, 2017 ABSTRACT Glioblastoma multiforme (GBM) is the most common and deadly brain cancer, characterized by its aggressive proliferation to adjacent tissue and high recurrence rate. We studied the efficacy and related mechanisms of the combination of cyclopamine (Cyp, a Sonic-hedgehog pathway (Shh) inhibitor) and temozolomide (TMZ, the clinically most used chemotherapeutic agent) in anti-GBM treatment. The micellarized Cyp (MCyp) showed better performance than Cyp solution in inhibiting GBM cells proliferation (3.77-fold against U87 MG cells and 3.28-fold against DBTRG-05MG cells) and clonogenity (1.35-fold against U87 MG cells and 2.17-fold against DBTRG-05MG cells), and preferred behavior of inhibiting cell invasion, colony formation through attenuated Gli1 expression. In addition, combination of MCyp...
4. Jin Seok Ahn - Cancer Research and Treatment
This study was conducted to investigate the clinical outcomes and recurrence patterns after definitive chemoradiotherapy (CRT) in patients with unresectable ...
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5. Medical expenses of urban Chinese patients with stomach cancer during ...
Apr 17, 2018 · Patients' data were collected if: (1) a patient was diagnosed with first primary stomach cancer; (2) his or her residence was registered as ...
In China, stomach cancer is the third most common cancer and the third leading cause of cancer death. Few studies have examined Chinese stomach cancer patients’ medical expenses and their associated trends. The Cancer Screening Program in Urban ...
6. Clinical significance of phlegm detoxification on survival with tumor ...
Objective To explore the effect of phlegm detoxification on the short-term curative and long-term survival with tumor in qi phlegm-poison type or yin phlegm- ...
Objective To explore the effect of phlegm detoxification on the short-term curative and long-term survival with tumor in qi phlegm-poison type or yin phlegm-poison type patients with advanced non-small cell lung cancer (NSCLC). Methods From August 2015 to July 2016, 207 advanced NSCLC patients, including 116 patients with qi phlegm-poison type and 91 patients with yin phlegm-poison type, were collected and divided into control group with western medicine treatment (n=80) and treatment group (n=127) with Yiqi Huatan Jiedu Decoction (for qi phlegm-poison type) or Yangyin Sanjie Decoction (for yin phlegm-poison type). After 4 courses of treatment, the short-time efficacy, TCM syndrome scores, Karnofsky scores were evaluated. The Kaplan-Meier curve were performed. Results There was no significant difference in the total effective rate between the control group (45.00%) and the treatment group (51.97%, χ2=0.954, P=0.329). The response rates of patients in treatment group with qi phlegm-poison party or yin phlegm-poison party were 89.55% and 83.33%, respectively, higher than that of control group (P<0.05). The TCM syndrome score and Karnofsky score were gradually decreased, and lower than before treatment and control group (all P<0.05). The survival rate (OS) of patients in treatment group with qi phlegm-poison type were 49.25%, higher than that in control group (all P<0.05), while the OS of patients in...
7. World Journal of Radiology - Baishideng Publishing Group
Wu Size, Tu Rong, Liang Xian. Patchy echogenicity of the liver in patients with chronic hepatitis B does not indicate poorer elasticity. Ultrasonography ...
8. International Journal of Clinical and Experimental Medicine
... are associated with esophageal cancer risk in a Chinese Han population. Int ... Ying-Chun Li, Rong Zhang, Ying Yang, Jia Li, Ke Zhu, Kun Yao, Zhuo-Gang ...
International journal of clinical and experimental medicine (ESCI: Web of Science) is an open-access online journal of medicine. It publishes scientific papers on medicine and related subjects including, but not limited to internal medicine, surgery, OB-GYN, pediatrics, infectious disease, physiology, pathophysiology, parasitology, anatomy and histology, embryology and pharmacology, etc.
9. Granzyme B PET Imaging of Combined Chemotherapy and ...
... with immune checkpoint inhibitor (ICI) monotherapy in cancer patients. In ... Results: [18F]AlF-mNOTA-GZP tumor uptake was able to clearly ...
Purpose: Chemotherapeutic adjuvants, such as oxaliplatin (OXA) and 5-fluorouracil (5-FU), that enhance the immune system, are being assessed as strategies to improve durable response rates when used in combination with immune checkpoint inhibitor (ICI) monotherapy in cancer patients. In this study, we explored granzyme B (GZB), released by tumor-associated immune cells, as a PET imaging-based stratification marker for successful combination therapy using a fluorine-18 (18F)-labelled GZB peptide ([18F]AlF-mNOTA-GZP). Methods: Using the immunocompetent CT26 syngeneic mouse model of colon cancer, we assessed the potential for [18F]AlF-mNOTA-GZP to stratify OXA/5-FU and ICI combination therapy response via GZB PET. In vivo tumor uptake of [18F]AlF-mNOTA-GZP in different treatment arms was quantified by PET, and linked to differences in tumor-associated immune cell populations defined by using multicolour flow cytometry. Results: [18F]AlF-mNOTA-GZP tumor uptake was able to clearly differentiate treatment responders from non-responders when stratified based on changes in tumor volume. Furthermore, [18F]AlF-mNOTA-GZP showed positive associations with changes in tumor-associated lymphocytes expressing GZB, namely GZB+ CD8+ T cells and GZB+ NK+ cells. Conclusions: [18F]AlF-mNOTA-GZP tumor uptake, driven by changes in immune cell populations expressing GZB, is able to stratify tumor response to chemotherapeutics combined with ICIs. Our results show that, while the immunomodulatory mode...
10. Medical expenditure for lung cancer in China: a multicenter, hospital ...
Aug 17, 2021 · Lung cancer is the most prevalent cancer, and the leading cause of cancer-related deaths in China. The aim of this study was to estimate the ...
Lung cancer is the most prevalent cancer, and the leading cause of cancer-related deaths in China. The aim of this study was to estimate the direct medical expenditure incurred for lung cancer care and analyze the trend therein for the period 2002–2011 using nationally representative data in China This study was based on 10-year, multicenter retrospective expenditure data collected from hospital records, covering 15,437 lung cancer patients from 13 provinces diagnosed during the period 2002–2011. All expenditure data were adjusted to 2011 to eliminate the effects of inflation using China’s annual consumer price index. The direct medical expenditure for lung cancer care (in 2011) was 39,015 CNY (US$6,041) per case, with an annual growth rate of 7.55% from 2002 to 2011. Drug costs were the highest proportionally in the total medical expenditure (54.27%), followed by treatment expenditure (14.32%) and surgical expenditure (8.10%). Medical expenditures for the disease varied based on region, hospital level, type, and stage. The medical expenditure for lung cancer care is substantial in China. Drug costs and laboratory test are the main factors increasing medical costs.
11. [PDF] 中 医 肿 瘤 治 疗 - Maciocia Online
As we have seen, the modern Chinese discussion of cancer focuses a lot on ... former two herbs have an anti-cancer effect and Lu Rong does not. Another ...
12. Vol 9, No 10 (October 30, 2020) - Translational Cancer Research
Oct 30, 2020 · ... Ying-Ju Chen, Chian-Pei Li, Yi-Hua Lai, Chang ... The clinical significance of RET gene fusion among Chinese patients with lung cancer.
Translational Cancer Research publishes the results of novel research investigations including risk assessment, cellular and prevention, detection, diagnosis and treatment of human cancers.
13. Faculty: Neurology - UT Southwestern, Dallas, Texas
Ying Xian, M.D., Ph.D. Associate Professor; Section Head - Research (Stroke ... Rong Zhang, Ph.D. Professor; Secondary Appointment: Internal Medicine ...
Meet UTSW's Neurology faculty, specialists in cognitive, movement, and neuromuscular disorders; MS; epilepsy; neuro-oncology; headache, trauma, and critical care.
14. Machine Learning Prediction of Early Recurrence in Gastric Cancer
Sep 12, 2024 · Preprints with The Lancet is part of SSRN´s First Look, a place where journals identify content of interest prior to publication.
Background: Patients with gastric cancer (GC) who experience recurrence within 2 years postoperatively (early recurrence [ER]) have a poor prognosis. This
